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Cirrhosis & Complications
EASL Studio Podcast S4 E4: JHEP Live: Is the term ‘decompensated cirrhosis’ outdated?

EASL Studio Podcast S4 E4: JHEP Live: Is the term ‘decompensated cirrhosis’ outdated?

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EASL Studio S4 E3: A 360 approach to beat alcohol-related liver disease

Description

Alcohol is the main cause of advanced liver disease and a major cause of hospitalisation and disability across the globe, including Europe. In this EASL Studio you will hear the patient perspective from an individual who has overcome this disease and listen to the faculty discuss the measures that can help prevent it.

Faculty

  • Prof. Ramon Bataller (Moderator)
  • Prof. Giovanni Addolorato (Faculty)
  • Prof. Peter Jepsen (Faculty)
  • Prof. Debbie Shawcross (Faculty)
  • Mrs Kristen Radage (Faculty)
  • Mr. Steven Rodrigues (Patient Perspective)

Related episodes

  • S3E5: JHEP Live: Stigma and alcohol
  • S3E4: Special Edition: Highlights of EASL NAFLD Summit 2022

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

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Metabolism, Alcohol & Toxicity
EASL Studio Podcast S4 E3: A 360 approach to beat alcohol-related liver disease

EASL Studio Podcast S4 E3: A 360 approach to beat alcohol-related liver disease

Podcasts
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General Hepatology
Quiz: A 62-year-old nurse with HBV-related cirrhosis and a history of recurrent hepatic encephalopathy (HE) is uncertain about the amount of daily protein intake recommended.

Quiz: A 62-year-old nurse with HBV-related cirrhosis and a history of recurrent hepatic encephalopathy (HE) is uncertain about...

Quiz
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ERN Rare-Liver on-demand Webinar: Biliary atresia

Description

In this ERN Rare-Liver webinar, held on 20 December 2022, the panel discussed how to screen for biliary atresia, future paradigms for treating biliary atresia and the role of the EBAR registry.

Targeted Audience

  • General practitioners
  • Hepatologists
  • Oncologists
  • Health care professionals

 

Chair

Ekkehard Sturm Ekkehard Sturm is currently leading the Pediatric Gastroenterology/ Hepatology group, University of Tuebingen, Children´s Hospital. This tertiary care facility is one of the largest national programs for pediatric liver transplantation. Research interests include Rare Liver Diseases and Liver Transplantation and Immunomodulation. His research interests are focussed on pathophysiology of cholestastic liver diseases, novel therapies including modifiers of the enterohepatic circulation and mesenchymal stroma cells for immmune-modulatory purposes. He was co-coordinator of the European Reference Network Rare Liver 2017-2021 and is leading the center for rare liver diseases at UK Tübingen.

Speakers 

Omid Madadi-Sanjani Omid Madadi-Sanjani is a board certified general surgeon and pediatric surgeon, with special interest in pediatric hepatobiliary surgery. He is the current lead of the pediatirc surgical BA working group at the Hannover Medical School and is the PI of a regional screening program for BA in Lower Saxony. Furthermore, he is part of the expert consultant group of the Federal Joint Committee for the screening of BA in Germany.
Orith Waisbourd-Zinman Orith Waisbourd-Zinman is an assistant professor of Pediatrics at Tel-Aviv University and is a pediatric gastroenterologist at Schneider Children’s Medical Center of Israel. Dr. Waisbourd has completed her GI training at the Children’s Hospital of Philadelphia and a post-doctoral fellow-ship at the University of Pennsylvania. Dr. Waisbourd’s research group studies mechanisms of cholangiocyte injury and recovery in biliary atresia and other cholangiopathies using human or-ganoids model as well as mice models.
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ERN Rare-Liver on-demand Webinar: Primary bile acid synthesis defects

Description

In this ERN Rare-Liver webinar, held on 13 December 2022, the panel discussed the diagnosis of bile acid synthesis and about the French experience in long-term treatment with cholic acid.

Targeted Audience

  • General practitioners
  • Hepatologists
  • Oncologists
  • Health care professionals

 

Speakers

Mara Cananzi Mara Cananzi (University Hospital of Padova).
Emmanuel Gonzales Emmanuel Gonzales is a pediatric hepatologist working in Bicêtre Hospital, AP-HP Université Paris-Saclay, France. He is actively involved in the field of rare liver diseases both at the national and at the ERN level.
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EASL Studio S2 E1: New treatment options for hereditary cholestasis syndromes: A game-changer?

Description

At the occasion of the Rare Liver Diseases Month, and EASL Studio hosted a special episode on the topic.
This episode focused on rare liver diseases, in particular, Progressive Familial Intrahepatic Cholestasis (PFIC). Discussions covered:

  • Clinical presentation of PFIC
  • Current therapeutic options
  • The introduction of IBAT/ASBT inhibitors and their impact
  • Clinical trials
  • Orphan drugs approved for PFIC
  • Interview with EMA on the orphan drug programme

This EASL Studio episode was supported by Albireo Pharma and Mirum Pharmaceuticals.

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Faculty

 
Verena Keitel Verena Keitel is Head of the Department of Gastroenterology, Hepatology and Infectious Diseases at the University Hospital Magdeburg in Germany. Her clinical and research focus are in cholestatic and hereditary liver diseases and the improvement of patient care. She is coordinator of a translational network for hereditary intrahepatic cholestasis (HiChol).
Thomspon Richard Thompson is Professor of Molecular Hepatology at King’s College London, and Honorary Consultant Paediatric Hepatologist at King’s College Hospital, London. His group identified BSEP and TJP2 as causes of PFIC; several other genes are on their way. Recent discoveries have been through the application of Whole Exome Sequencing. He is a member of the NIDDK-funded ChiLDReN collaboration. At King’s College Hospital Professor Thompson runs a diagnostic laboratory, using targeted Next Generation Sequencing, for genes involved and cholestasis and other liver phenotypes, and is the Clinical Lead for the 100,000 Genomes Project.
Verkade Henkjan J. Verkade is a pediatric gastro/hepatologist at the Beatrix Children’s Hospital of the University Medical Center Groningen, The Netherlands. He received his PhD degree in Medicine cum laude at the University of Groningen on the thesis entitled “Lipid absorption and metabolism”. Henkjan Verkade was a post-doctoral fellow at the University of Alberta, Edmonton, Canada. Henkjan Verkade combines clinical work in pediatric gastro/hepatology with clinical and fundamental research projects. He is a member of national and international professional associations and organizations. For the European Society Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN), he served as Chair of the Hepatology Committee and member of the Council (2016-2020). His current research projects involve intestinal lipid absorption and metabolism, the enterohepatic circulation, and pediatric liver disease (biliary atresa, liver transplantation, familial cholestatic syndromes). He has authored more than 250 peer-reviewed publications and more than 15 book chapters. Since 2019, he is associate editor of the Journal of Pediatric Gastroenterology and Nutrition. He has supervised 45 PhD students up till successful completion of their thesis.

Special participation

Kristina Larsson, European Medical Agency

Industry representatives

 
Villy Dr Valcheva is the VP, Head of Medical Affairs Europe at Albireo Pharma. For 2 years she has been building and leading the medical organization in Europe with dedication to provide hope to patients and their families with rare liver diseases such as PFIC, Alagille syndrome and Biliary atresia. Velichka (Villy) has more than 20 years of experience in the pharmaceutical industry including medical leadership positions across multiple disease areas. Before joining Albireo, she worked extensively in the area of oncology, most recently as the Global Medical Lead for Liver Cancer at Ipsen. In addition, she worked in cardiovascular and rare diseases as the Global Medical Lead for Familial Hypercholesterolemia at Sanofi.
Pamela Vig Dr Pamela Vig, Ph.D, is head of R&D at Mirium, where she leads the scientific and clinical aspects of drug development and research, and medical affairs. She has more than 25 years of industry experience in clinical development, medical affairs and translational science in various liver diseases including hepatitis B (HBV), hepatitis C (HCV), nonalcoholic steatohepatitis (NASH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and cholestatic liver disease. She has held leadership roles as vice president of clinical research and discovery at Allergan plc and Tobira, as well as vice president of clinical research at Presidio Pharmaceuticals, Inc. She also served as director, global medical affairs, at Johnson & Johnson, and has held positions in clinical research and development at Idenix Pharmaceuticals and Gilead Sciences, Inc. She is currently a member of the PSC Forum Steering Committee as well as co-chair for the pediatric cholestatic disease working group under the Forum for Collaborative Research.
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EASL Studio Special Edition: Live from Viral Hepatitis Elimination Conference 2022

Description

The WHO goal of eliminating viral hepatitis by 2030 has led to a surge in activities to achieve a world free from viral liver disease. What steps must be taken? How do you define sustainable elimination? Listen to the experts debriefing the Viral Hepatitis Elimination Conference 2022.

Discover the highlights of the conference and learn more about what successful countries have done to achieve viral hepatitis elimination.

 

 

Moderaor

 
Graham Foster Graham Foster is the Professor of Hepatology at Queen Mary, University of London and a consultant at Bart’s Health in East London.  He has a long-standing interest in the management of chronic viral hepatitis and runs a clinical research program studying novel therapies for viral hepatitis, it’s natural history and impact upon patients and their communities. . He leads a national study investigating community screening for viral hepatitis. Prof Graham also supervises a laboratory research program investigating novel replication models for hepatitis C.  He is the editor of The Journal of Viral Hepatitis and has published widely in the field of viral liver disease. He is Vice Chairman of the NHS England Advisory Group on hepatitis and a member of a number of patient advocacy groups.

Faculty

 
John Dillon John Dillon is Professor of Hepatology and Gastroenterology and principal investigator, in the Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee. He is also an Honorary Consultant with NHS Tayside, leading a busy general hepatology service and a research group. He is Vice President for Hepatology of the British Society of Gastroenterology and was President of the Scottish Society of Gastroenterology. His research interests includes: new pathways of care for patients with abnormal LFTs, for people infected with HCV, new therapies for HCV infection, as well as novel diagnostics and treatments for NAFLD. His research activities stretch from the bench to the bedside and out into the community.
Philippa Easterbrook

Philippa Easterbrook is Senior Scientist within the Global Hepatitis Programme in the HIV department at the World Health Organisation Headquarters in Geneva. For the last five years she has led the development and implementation of global normative guidance in the use of antiretroviral therapy, and hepatitis B and C management and testing, and support to low and middle-income countries in hepatitis testing and treatment scale-up. She graduated in Medicine from University of Cambridge, and completed her training in general medicine and infectious diseases in London, Oxford and Birmingham, and in public health and epidemiology at Johns Hopkins University in the United States. She was Senior Lecturer in Infectious Diseases and Epidemiology at Imperial College, and then Head of Department and Professor of HIV Medicine at King´s College London for eleven years. She also served as Head of Research at the Infectious Diseases Institute, Makerere University, Kampala during a sabbatical. Her research activities have encompassed epidemiology, clinical trials, operational and qualitative research, as well as collaborative pathogenesis studies on the mechanisms of resistance to HIV, and has published more than 200 peer-reviewed articles.

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EASL Studio S2 E2: Fats or carbs, who is the real villain?

Description

Obesity is a global health problem that is quickly becoming the leading cause of fatty liver disease. In honour of World Obesity Day (4 March), and to address this growing public health issue, we took a closer look at diets.

  • What is the role of fats and carbohydrates on liver fat content?
  • What are the current dietary recommendations?
  • What are randomised controlled trials showing us about polyunsaturated (PUFA) and saturated fat (SFA) (e.g. palm oil)?

Moderator

 
Shira Zelber-Sagi Head, School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel Department Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv. Prof. Zelber-Sagi is a clinical dietitian, Epidemiologist, and researcher in nutritional epidemiology and NAFLD, and other chronic co-morbidities. Currently, Prof. Zelber-Sagi is a full professor and the Head of the School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa. A member of the EASL Policy and Public Health Committee and the United European Gastroenterology (UEG) Policy and Public Health Committee. Founder of the Gastroenterology forum of the Israeli dietitians’ association.

Faculty

 
Bernadette Moore

Bernadette Moore is Associate Professor of Obesity and Head of Graduate School at the University of Leeds in the UK. A multidisciplinary Nutritional Scientist, her research has focused on the role of hepatic nutrient metabolism in obesity and NAFLD, and employed a variety of genomic, proteomic, and systems biology tools alongside nutritional intervention studies. Recent work encompasses strands of food policy and food systems related to childhood obesity, food poverty and malnutrition. She has published >50 peer-reviewed papers, editorials and book chapters, and was the recipient of the 2018 Nutrition Society Silver Medal for Research Excellence in a Young Investigator.

Yftach Gepner Dr Yftach Gepner joined the School of Public Health, Tel Aviv University, at 2018 and his research focuses on understanding the impact of exercise training, combined with dietary strategies, on body metabolism, composition and physical performance across a range of populations. Dr Gepner is using cutting-edge technologies, including magnetic resonance imaging (MRI) for assessing muscle damage and adipose tissue distribution, doubly labelled water to assess energy expenditure and labelled amino acid to determine protein synthesis by muscle biopsy. By combining applied and mechanistic metabolism and physiology adaptation studies using advanced monitoring devices, his goal is to elucidate the unique beneficial effect from physical activity.
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EASL Studio S2 E3: Interview with Stephan Urban - From bench to bedside: Process of developing the first HBV/HDV entry inhibitor

Description

In this episode of EASL Studio, a very special interview with Prof. Stephan Urban talking about his journey of the discovery and development of the first HBV/HDV entry inhibitor.

  • Where did the story begin and what were the major breakthroughs and challenges?
  • What are the mechanisms of viral entry inhibitors and how it differs from direct acting antivirals mode of action?
  • How does it impact the future of HBV/HDV treatment landscape?

This project has been made possible with the provision of a financial grant from Gilead Sciences Europe Ltd.
EASL has received no input from Gilead with regard to the content of this programme.

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Speakers

 
Stephan Urban Professor Stephan Urban is head of the Translational Virology unit at the Department of Infectious Diseases, Molecular Virology at Heidelberg University. Between 2008 and 2012 he was Project coordinator of the BMBF-network “Innovative Therapies” and is now coordinating the Hepatitis D project within the German Centre of Infection Research (DZIF). He has published in numerous peer reviewed journals on Hepatitis B, C and D. He is the recipient of the Pettenkofer Price of the Pettenkofer Foundation. In 2014 he was awarded with the 1. DZIF Research Award. In 2021, he received the The Distinguished Award in Hepatitis B Research.
Thomas Berg

Professor Dr. Thomas Berg is Head of the Division of Hepatology, Department of Medicine II, at the Leipzig University Medical Center, Germany, and Chair of the University Liver Tumor Center, and Vice-Chair of the University Liver Transplant Center Leipzig. He is Secretary General of the European Associations for the Study of the Liver (EASL), Board member of the EASL International Liver Foundation (EILF) and served the Journal of Hepatology as Co-Editor between 2014 and 2019. He has published more than 440 articles in peer-reviewed journals and more than 100 reviews and textbook contributions. His h-index is 76 (Scopus).

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EASL Studio S2 E5: New era for science dissemination: The role of social media

Description

In recent years social media has become a powerful tool, not only for science dissemination, but also for discussing data and networking.

  • What is the impact of dissemination via social media?
  • How is social media changing the way data is communicated?
  • Should social media activity be considered a professional endeavour?

Watch the episode to find out.

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Moderator

 
Jesus Banales

Prof. Jesús Bañales is Head of the Liver Diseases Group at Biodonostia Health Research Institute (Donostia Univ. Hospital) in San Sebastian, Spain. His group is focused on studying the the molecular mechanisms involved in liver pathobiology, with special attention to cholestatic liver diseases, NAFLD, and liver cancer, and looking for novel diagnostic and therapeutic strategies. Regarding social media, he is Journal of Hepatology Website/Social Media co-Editor.

Faculty

 
Ahmed Elsharkawy Dr Ahmed Elsharkawy is a consultant transplant hepatologist at the Queen Elizabeth Hospital and honorary senior lecturer at the University of Birmingham as well as a Fellow of the Royal College of Physicians of London. His clinical interests include viral hepatitis, liver transplantation, polycystic liver disease, DILI, PBC, ALF, ACLF, NAFLD (especially in the context of hepatitis B) and cirrhotic sarcopaenia. He has pioneered novel approaches to the management of hepatitis C in the community.
Elliot Tapper

Elliot B. Tapper MD is an Associate Professor in the Division of Gastroenterology where he is director of the Michigan Cirrhosis Program. He is an NIH-funded investigator aiming to improve outcomes for patients with cirrhosis, with a focus on improving quality of care and symptom management. He helped found the twitter community called #livertwitter and can be found on twitter @ebtapper where he promotes all things hepatology. He co-ordinates social media for the Journal of Hepatology with Jesús Bañales.

Juan Turnes

Dr Juan Turnes is Head of Gastroenterology and Hepatology Department at Complexo Hospitalario Universitario de Pontevedra and Associate Professor at the University of Santiago de Compostela, Spain. He leads and investigator group focused in viral hepatitis and NAFLD. Regarding social media, he is in charge of the communication department of the Spanish Association for the Study of the Liver and he is also the associate editor of the journal Liver International. He uses to promote discussion on the #livertwitter community and regularly shows data analysis of this network on Twitter account @jturnesv.

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EASL Studio S2 E6: Should anticoagulants be given to patients with cirrhosis to improve outcome?

Description

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis were recently released. Join the faculty as they discuss:

  • What effects do anticoagulants have on survival and liver related events in cirrhosis?
  • What are the mechanisms of action?
  • What type of anticoagulants should be used in patients with cirrhosis?

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Moderator

 
Pierre-Emmanuel Rautou Pierre-Emmanuel Rautou (MD, PhD) is a clinical specialist in Hepatology and has been a Professor of Hepatology at Université Paris-Cité and Hôpital Beaujon (Clichy, France) since 2016. He is the head of the splanchnic hemodynamic laboratory at Beaujon Hospital (Clichy, France). He is also leads an Inserm team dedicated to the study of the role of vessels in liver diseases, at the INSERM Unit 1149 (Paris Research Center on Inflammation). His research is focused on the role of vessels in liver diseases. Specifically, he is interested in primary vascular liver diseases (Budd-Chiari syndrome, portal vein thrombosis and portosinusoidal vascular disorder), as well as in vascular involvement in common liver diseases development and complications (extracellular vesicules, coagulation, endothelial cells).

Faculty

 
Erica Vila

Erica Villa, MD, is a Senior Professor of Gastroenterology at the University of Modena and Reggio Emilia. She treats patients with liver disease, and has particular expertise in cirrhosis, portal hypertension and HCC. Dr. Villa has completed many clinical studies that have led to identifying factors like menopause or hormonal status as critical in the progression of chronic liver disease. In the last years she has studied the factors determining HCC biologic aggressiveness as well as the relationship between coagulative status and progression of cirrhosis and its complications. Lately, she has led the panel in charge of writing the EASL CPGs on prevention and management of bleeding and thrombosis in patients with cirrhosis.

Patrick Northurp

Patrick Northup is professor of medicine and surgery and medical director of liver transplantation at the Transplant Institute of New York University Langone Health in New York City. While fundamentally a clinician educator, Dr Northup has research interests in vascular disorders of the liver, coagulopathy of liver disease, portal vein thrombosis, anticoagulation in liver disease, liver transplantation and organ allocation. He is a fellow of the American Association for the Study of Liver Diseases and the American College of Gastroenterology. Dr Northup is a consultant to the NIDDK, FDA, and UNOS and is a prior recipient of the AASLD Jan Albrecht Clinical Research Award.

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