This episode focuses on Hepatitis D (HDV), which is less common than hepatitis B or C but is a serious disease that often affects underprivileged and vulnerable populations. HDV has long been neglected and even though it is a highly aggressive viral hepatitis which can rapidly progress to cirrhosis and liver cancer, it remains under-recognised, underestimated, and under-treated. What is the status of Hepatitis D elimination globally and what challenges do we still face? Which strategies would be best deployed against Hepatitis D? How can lessons learned about Hepatitis C elimination be applied to Hepatitis Delta?