As part of the International Liver Congress (ILC) 2021, the EASL Takeaways take a look at key topics from the congress, with leading experts discussing the most impactful science and putting it into perspective. In this session, Professors Ana Lleo, Saskia van Mil and Ulrich Beuers cover the most newsworthy developments from three topics – autoimmune hepatitis (AIH), cholestatic liver diseases and rare hereditary liver diseases.

Professor Lleo first presents abstracts on key risk factors associated with AIH recurrence and the role of multiparametric MRI as a non-invasive tool to assess AIH disease activity, before the panel assess their clinical implications. The discussion then moves on to surveillance strategies for primary sclerosing cholangitis. Finally, Professor van Mil highlights abstracts on genotype-selected risk of liver disease and HCC in people with alpha-1 antitrypsin deficiency, and on the efficacy of GNT0003, a novel gene therapy for patients with Crigler-Najjar Syndrome.

Biographies

Ana Lleo Ana Lleo is an associate professor of internal medicine in Humanitas University. She is responsibility of the Hepatobiliary Immunopathology Laboratory in collaboration with the Hepatobiliary Surgery Unit. Prof. Lleo specifically works on cholangiocarcinoma and her areas of scientific expertise are biliary disorders, with particular attention for cholangiocyte biology and liver innate immune response. She is also a member of the “European Network for the Study of Cholangiocarcinoma (ENS-CCA)”.
Saskia van Mil Saskia van Mil is Professor of Molecular and Translational Metabolism at the University Medical Center Utrecht, The Netherlands. She is also a member of the Scientific Committee of the European Association for the Study of the Liver (EASL). Her group has studied the molecular and translational aspects of energy metabolism in the liver and the intestine, with a specific focus on the role of FXR in metabolic disorders (e.g. NASH) and disorders of intestinal integrity (e.g. IBD) and optimising the efficacy of FXR agonist treatment.
Ulrich Beuers Professor Ulrich Beuers is a Professor of Gastroenterology and Hepatology at the University Medical Centers in Amsterdam, The Netherlands. He is also the educational councillor of the European Association for the Study of the Liver (EASL). His research focuses on the pathophysiology and therapy of cholestatic liver diseases.