Information message

In order to see all the search results and access content, you must log in. Please use the Log-in button at the top of the page.

Displaying 229 - 240 of 440

EASL Studio S2 E7: JHEP Live on critical appraisal of classification, diagnosis and treatment of hepatic encephalopathy

Description

Hepatic encephalopathy (HE) is a common complication of advanced liver disease. The first-line treatment includes agents that counter the high levels of ammonia, which are thought to play a central role in the disease.

  • What information do ammonia measurements provide and what is the relationship with hepatic encephalopathy?
  • Is the term “Covert HE” clinically useful?
  • And, is it time to rethink the standard of care?

Discussions in this EASL Studio JHEP Live episode will revolve around a recently published article. In addition, the Q&A summary is displayed below the video. Please login to your free EASL Campus account to share your questions and thoughts using the forum available on this page!

This EASL studio is supported by Norgine and Umecrine Cognition. EASL has received no input from Norgine and Umecrine Cognition with regards to the content of this programme.

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

Q&A document

EASL Studio Q&A for JHEP Live episode

 

Host

 
Paolo Angeli Paolo Angeli is Head of the Unit of Internal Medicine and Hepatology and Full Professor of Medicine at the University of Padova, Italy. He leads a research team which focuses on the pathophysiology and treatment of acute, chronic, and acute-on-chronic liver failure and liver transplantation, and has authored numerous international guidelines and positional papers for EASL. Professor Angeli is Editor-in-Chief of the Journal of Hepatology and Chair of the EASL-CLIF Consortium (European Association for the Study of Chronic Liver Failure).

Faculty

 
Rajiv Jalan Rajiv Jalan is a clinician scientist. He is a Professor of Hepatology at UCL, Scientific Director of EFCLIF and the previous Editor in Chief of Journal of Hepatology. His main interests are in understanding the molecular mechanisms underlying the pathogenesis of organ dysfunction in liver failure and using the knowledge to develop new therapies. His research has led to discovery of several novel therapeutic approaches, the publication of over 480 peer-reviewed papers and his H-Index on Google Scholar is 100.
Debbie Shawcross

Debbie Shawcross is a Clinician Scientist and Professor in Hepatology and Chronic Liver Failure at the Institute of Liver Studies (ILS), King’s College Hospital and the James Black Centre, King’s College London. She works as a Consultant Hepatologist on the King’s Liver Unit with a specialist interest in hepatic encephalopathy and the complications of cirrhosis. The aims of her research programme are to characterise the immunobiology of chronic liver failure focusing specifically on the gut-liver-brain axis in the context of the gut microbiome as a driver of immune dysfunction, inflammation, and encephalopathy.  She is also the Chief Investigator of the NIHR-funded EME UK multicentre randomised placebo-controlled clinical trial of faecal microbiota transplantation (capsules) [PROMISE Trial] in patients with metabolic-associated and alcohol-related cirrhosis.

Sara Montagnese

Sara Montagnese is an Associate Professor of Medicine and Honorary Consultant Physician at Padova University Hospital, in Italy. From 1 June 2022 she will also be a part-time Full Professor of Chronobiology at the University of Surrey, in the UK. She is Past President of the International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) and a member of the Governing Boards of the Italian Association for the Study of the Liver (AISF) and the European Biological Rhythms Society (EBRS). She is Associate Editor and Special Section Editor (Snapshots) of Journal of Hepatology, and Associate Editor of Frontiers in Physiology – Chronobiology. She has also been part of the Editorial Boards of Hepatology and BMJ-Open Gastroenterology.

Log in to post comments

EASL Studio S2 E9: YI Choice: Propelling liver cell biology into the third dimension

Description

Reduce, Refine, Replace. Developed over 50 years ago, the 3Rs provide a framework that urges researchers to think carefully about methods used to investigate scientific questions. In this episode of EASL Studio, we took a closer look at the third R, Replace. With the World Day for Laboratory Animals fast approaching, we discussed how to propel liver cell biology into the third dimension.

  • What are the advantages of 3D cultures?
  • Can liver cell types be studied in representative manner using 3D cultures?
  • More importantly, which part of animal research can be replaced by 3D cell culture experiments?

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

This and more in EASL Studio: YI Choice.

Chat reply

Host

 
Philipp Schwabl

Philipp Schwabl is a young physician-scientist, focusing on end-stage liver disease, portal hypertension and translational research. He had his training at the Medical University of Vienna and is currently an EASL Sheila Sherlock research fellow at the UCL Institute for Liver & Digestive Health in London. Being part of the EASL YI Task Force, he engages in making liver research more accessible and exciting for young investigators. 

Moderator

 
 Krista Rombouts Krista Rombouts PhD is Professor at the Institute for Liver and Digestive Health, Regenerative Medicine and Fibrosis Group, Head of Centre for Tissue Repair and Regeneration, University College London (UCL), UK. Her current research interests are fibrogenesis with focus on Hepatic Stellate Cell behaviour; liver cancer cell biology with focus on fibrotic stroma cell interaction; NAFLD-NASH and innovative 3D cell culture systems for improvement of new target identification and drug development. Prof Rombouts was Editorial Board Member of AJP and Journal of Hepatology. She has international academic collaborators and industrial partners and is shareholder and consultant of UCL Spin-out Engitix Therapeutics Ltd since 2016.

Faculty

 
Ludovic Vallier Professor Ludovic Vallier was the manager of the NIHR Cambridge Biomedical Research Centre human Induced Pluripotent Stem Cells core facility between 2009-2022 and co-deputy director of the Wellcome and MRC Cambridge Stem Cell Institute until 2022. He recently joined the Berlin Institute of Health (BIH) as Einstein Professor of Stem Cells Biology. His group based at BIH Center for Regenerative Therapy (BCRT) takes advantage of human pluripotent stem cells and primary organoids to generate liver cells with a clinical interest for disease modelling and cell-based therapy. More precisely, they investigate the molecular mechanisms controlling cell fate decisions during human liver development and exploit the resulting knowledge to produce hepatocytes and cholangiocytes. The resulting cells are currently used to study metabolic disorders and to develop regenerative medicine applications against liver diseases.
Pedro Baptista Prof. Pedro Baptista is currently a Group Leader at the Aragon Health Research Institute (IIS Aragon) in Zaragoza, Spain and the founder of the Organ Bioengineering and Regenerative Medicine Laboratory at the Aragon Biomedical Research Institute (CIBA), Zaragoza, Spain. He is also an Assistant Professor at the Biomedical and Aerospace Engineering Department of University Carlos III of Madrid, Spain. His current research focuses on investigating liver stem cell biology, developing novel methods to expand fetal and adult human stem/progenitor cells and in making the long-term transplantation of these lab-grown organs a reality. Prof. Pedro Baptista is also interested in applying bioengineered hepatic tissues and organs to study developmental biology, physiology and drug discovery.
Log in to post comments

EASL Studio S2 E10: LITMUS: Defining the colour of NAFLD

Description

LITMUS is a large consortium that reunites clinicians and scientists across Europe with the common goal of developing, validating, and qualifying better biomarkers for NAFLD. In this episode of EASL Studio, the following questions are addressed:

  • Why do we need more specific biomarkers?
  • Which populations should be included in trials and registries for the search of new biomarkers?
  • How do we take different patient demographics, co-morbidities and concomitant treatments, into consideration?
  • Are new sophisticated biomarkers necessary?

 

This EASL Studio has been sponsored by Intercept Pharmaceuticals Europe Limited. The sponsor have had no editorial control over the content featured.
Intercept’s subsidiaries and operations in Europe, Canada, and all other markets outside of the U.S. were acquired by Advanz Pharma on 1st July 2022. Intercept- branded videos, which are available on this site, all concern events which took place prior to 1st July 2022. For more information learn more here.

 

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

Survey

Moderator

 
Massimo Pinzani

Massimo Pinzani is Professor of Medicine at University College London (UCL), London, United Kingdom. He is a clinical and translational hepatologist, Sheila Sherlock Chair of Hepatology and Director of the UCL Institute for Liver and Digestive Health, Division of Medicine. He is also one of the pioneers in the research dedicated to cellular and molecular mechanisms of liver fibrosis and relative diagnostic and therapeutic approaches. His current research focus is regenerative medicine and on the development of extracellular matrix scaffold of liver, pancreas and small intestine for cell bioengineering and 3D disease modelling. He served as Educational Councillor and member of the governing board of the European Association for the Study of the Liver (EASL).

Faculty

 
William Alazawi William Alazawi is Professor of Hepatology at Queen Mary University of London and a Consultant Hepatologist. Professor Alazawi looks after patients with a broad range of liver diseases, with particular interest in non-alcoholic fatty liver disease. He leads a thriving translational and clinical research group, funded by Medical Research Council, Wellcome and charities. 
Quentin Anstee Prof Quentin M. Anstee is the Chair of Experimental Hepatology and the Deputy-Dean of Research & Innovation in the Faculty of Medical Sciences, Newcastle University, UK. A practicing clinician, he is also an Honorary Consultant Hepatologist in the Liver Transplant Unit at Newcastle’s Freeman Hospital, where he leads one of the largest Non-Alcoholic Fatty Liver Disease (NAFLD) clinical services in the U.K. He coordinates two major international research consortia studying NAFLD pathogenesis and developing/validating accurate biomarkers to assist the diagnosis, risk-stratification and monitoring of patients with NAFLD: ‘EPoS’ Elucidating Pathways of Steatohepatitis and ‘LITMUS’ Liver Investigation: Testing Marker Utility in Steatohepatitis. He has established a pan-European NAFLD Registry and is an Associate Editor of the Journal of Hepatology.
Log in to post comments

EASL Studio S2 E18: How can our response to the climate crisis transform and improve hepatology services?

Description

Issues of climate change, global warming and sustainability are taking centre stage in political agendas across the globe, causing major restructuring in many sectors. But, what about the healthcare sector?

  • How is climate change affecting healthcare?
  • How big of a problem is climate change for liver care?
  • What public health strategies can be implemented to mitigate the effects of climate change?

You can find more information about the impact of climate change on liver disease care in this publication.

Related episodes:

EASL Studio – S2E12 – Nurse and AHP Focus: Sustainable Hepatology – Insights in nursing initiatives

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

 

Moderator

 
Aleksander Krag

Aleksander Krag is Professor and Head of Hepatology at University of Southern Denmark and Odense University Hospital. Main research areas are within complications to cirrhosis, portal hypertension and alcoholic liver disease. He is involved in a number of collaborations, including being Coordinator in the H2020 project GALAXY: Gut and liver axis in alcoholic liver fibrosis.

Faculty

 
Mhairi Donnelly Mhairi Donnelly is a Consultant Hepatologist in the Royal Infirmary of Edinburgh, Scotland. She is a member of the British Society of Gastroenterology Liver Section, and the Climate Change and Sustainability working group.
Adrian Reuben Adrian Reuben BSc, MBBS, FRCP, FACG, FAASLD, AGAF is an Emeritus Professor of Medicine at the Medical University of South Carolina and was appointed Honorary Visiting Professor at The Institute of Hepatology KCL. He had a laboratory-based career which focused initially on biliary lipid secretion, later hepatic fibrogenesis and ultimately hepatic regeneration. He is one of two representatives for the AASLD on a Multisociety Task Force, which is charged with devising a Strategic Plan that addresses a response to the interaction between Climate Change and Digestive Diseases.
William Stableforth William Stableforth is a hepatology consultant in Cornwall, UK with an interest in climate and health. He is a former clinical lead for environmental sustainability at the Royal Cornwall Hospital. He is a founder member of the Green Endoscopy Network and the Health Declares Climate Emergency network. He has been a climate activist for many years, the climate crisis is a healthcare crisis.
Log in to post comments

EASL Studio S2 E11: JHEP Live: Stop Nuc in HBeAg negative patients

Description

Nucleos(t)ide analogues (NUCs) have been developed over the past decade and currently play a crucial role in the treatment of chronic hepatitis B infections. Studies show that, patients that test negative for the hepatitis B e antigen (HBeAg) may be cured by stopping NUC therapy, however this is seldom done in clinical practice.

  • Where do the current guidelines stand on the discontinuation of NUC therapy in different patient populations?
  • What does the data say about the role of flare-ups after treatment is stopped?
  • Which parameters exist for predicting a functional cure following treatment cessation?

Join the faculty in this EASL Studio JHEP Live episode discussing an Expert opinion article published last year in the Journal of Hepatology.

If you are interested in the topic of Viral Hepatitis, watch these related episodes:

S2E3: Interview with Stephan Urban - From bench to bedside: Process of developing the first HBV/HDV entry inhibitor

S2E8: Treatment of HBV-HDV coinfection in the era of entry inhibition

Special Edition: Live from Viral Hepatitis Elimination Conference 2022

This EASL studio is supported by GlaxoSmithKline. EASL has received no input from GlaxoSmithKline with regards to the content of this programme.

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Moderator

 
Markus Cornberg His clinical focus is the treatment of patients with infectious liver diseases and his basic science research focuses on investigating cellular immune responses for disease progression and treatment response in patients with viral hepatitis. Markus Cornberg is Professor Infectious Diseases and Senior Consultant at the Department of Gastroenterology, Hepatology and Endocrinology at the Medical School. Since 2019, he is Clinical Director Helmholtz Centre for Infection Research and Director of the Centre for Individualized Infection Medicine (CIIM).  In 2012, Prof. Cornberg was the German representative for the drafting of the EASL Hepatitis B Guideline. From 2017 to 2020, he served on the Scientific Committee and Governing Board of the European Association for the Study of the Liver (EASL).

Faculty

 
Thomas Berg

Professor Dr Thomas Berg is Head of the Division of Hepatology, Department of Medicine II, at the Leipzig University Medical Center, Germany, and Chair of the University Liver Tumor Center, and Vice-Chair of the University Liver Transplant Center Leipzig. He is Secretary General of the European Associations for the Study of the Liver (EASL), Board member of the EASL International Liver Foundation (EILF) and served the Journal of Hepatology as Co-Editor between 2014 and 2019. He has published more than 440 articles in peer-reviewed journals and more than 100 reviews and textbook contributions. His h-index is 76 (Scopus). 

Anna Lok

Dr Lok is currently Director of the Hepatology Program and Assistant Dean for Clinical Research at the University of Michigan. Her research focuses on natural history and treatment of hepatitis B and C and, more recently, includes liver cancer and fatty liver. She has mentored more than 60 fellows and junior faculty from all over the world and received many awards including an International Recognition Award from the European Association for the Study of the Liver in 2018, and a Distinguished University Professorship from the University of Michigan in 2019. Dr Lok served as Associate Editor of Hepatology in 2001-2006 and Senior Associate Editor of Gastroenterology in 2011-2012. Dr Lok served as AASLD President in 2017.

Yuen

Professor Yuen is the Chair and Chief of the Division of Gastroenterology and Hepatology at the University of Hong Kong. His research interests include prevention, natural history, serology, virology and treatment of chronic hepatitis B and C, and hepatocellular carcinoma. He is one of the top internationally renowned researchers in the field of hepatitis B disease. As a world-class clinician scientist, Professor Yuen is now leading most of the international trials examining new drugs including antiviral and immunomodulatory agents for the treatment of chronic hepatitis B. He is also actively performing cutting edge research on novel markers for hepatitis B infection and occult hepatitis B infection.

Log in to post comments

EASL Studio S2 E12: Nurse and AHP Focus: Sustainable hepatology – Insights in nursing initiatives

Description

In honour of the International Nurse Day (12 May), and to discuss sustainability in liver care, this week we will gain some insights into the impact of nursing initiatives.

  • What is sustainable liver care?
  • What role do nurses currently play?
  • What current nurse-driven activities are promoting a sustainable clinical practice?

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Moderator

 
Patrizia Kunzler-Heule

Dr Patrizia Künzler-Heule is a Swiss registered nurse additionally prepared with a PhD in Nursing Science. For 25 years, she works in the clinic for Gastroenterology/Hepatology at the Cantonal Hospital St. Gallen. She has developed an advanced practice nurse role with a focus on nursing care for patients with chronic liver diseases. At the University of Basel, she is doing her research and give lectures especially on programs/interventions for enhanced self-management and behavioral change. Since 2020, she is chair of the EASL nurses & AHP taskforce.

Speakers

 
Elizabeth Farrington Elizabeth Farrington has worked within the Hepatology service at the Royal Cornwall Hospital, United Kingdom, since 2003. She has a well -established role as Consultant Nurse, with an extensive portfolio across education, research, leadership, consultancy, and clinical expertise. She has been involved with a number of national strategic projects, working with the Department of Health, Public Health England, NHS England, Health Education England and the Lancet. In addition, she maintains representation on national liver committees and specialist working groups, being passionately committed to the patient journey, with a keen interest in service development, stakeholder involvement and partnership working across primary and secondary care services. Elizabeth Farrington is also Clinical Director for Specialist Services and Surgery. She is committed to the delivery of sustainable healthcare, striving to utilise resources in a way that do not adversely affect the health of the population, whilst developing strategies that contribute to the commitments of delivering a net zero NHS.
Roz Davies

Roz Davies is a General Manager and leads for the Royal Cornwall Hospitals Trust with the operational delivery of their Net Zero Green Plan. With 27 years of NHS grass roots experience and award winning sustainable credentials, practical, hard work has delivered the actions needed to create a Greener Cornwall and NHS.

Log in to post comments

EASL Studio S2 E13: Digital Pathology

Description

In the assessment of disease stage, liver pathology is still largely based on semi-quantitative methods. Recent advances in whole slide imaging have opened the door for the use of artificial intelligence (AI) and the creation of machine learning (ML) algorithms.

  • What exactly is digital pathology?
  • How can it be implemented in different disease areas?
  • Can it be used in routine clinical practice?

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Moderator

 
Tania Roskams

Prof. Dr Tania Roskams is Head of the Department of Imaging and Pathology of the University of Leuven, Belgium. She also heads the research groups of Translational Cell-and Tissue Research and is a professor in Anatomy, Histology and Liver Pathology in the Medical Faculty of the same university. Prof. Roskams was an independent member of the Scientific Board of the United European Gastroenterology Federation (2005-2011) and a member of the Governing Board of the European Association for the Study of the Liver (2009-2012). Her research interests include liver stem/progenitor cells in liver regeneration and carcinogenesis. She also specialises in the characterisation of animal models of human diseases.

Faculty

 
Dina Tiniakos Dina Tiniakos is Professor of Pathology & Director, Dept of Pathology, Aretaieion Hospital, Medical School, National & Kapodistrian University of Athens, Greece and academic hepatopathologist at the Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, UK. She is Past President of the European Society of Pathology (2019-2021) and Chair, Equality & Diversity Taskforce, United European Gastroenterology. Her main research interests include fatty and autoimmune liver disease and hepatocarcinogenesis and co-leads several European consortia on liver pathology. She is also central pathologist in major international clinical trials for non-alcoholic steatohepatitis. Dina is currently Associate Editor of “Histopathology” and Editorial Board member of “Journal of Hepatology” and “Annals of Gastroenterology”.
Darren Treanor

Prof. Darren Treanor is a consultant pathologist at Leeds Teaching Hospitals NHS Trust, honorary professor of pathology at the University of Leeds, adjunct professor in digital pathology at Linköping University, Sweden and Digital Pathology Lead for the UK Royal College of Pathologists. Dual qualified in medicine and computing, he has co-authored over 150 papers on digital pathology. He is director of the £50m National Pathology Imaging Co-operative which will deploy digital pathology across the North of England, and in two national networks supporting rare tumours - creating a unique national infrastructure for artificial intelligence.

Log in to post comments

EASL Studio Special Edition: Unexplained acute hepatitis in children

Description

Since the beginning of April 2022, over 300 probably cases of acute hepatitis of unknown origin have been detected in children across Europe, Israel, Japan and the United States of America. The severity is such that ~17% of the infected children had undergone liver transplantation and one death has been reported.

In this Special Edition EASL Studio episode, we will discuss the aetiology and epidemiology for this outbreak as well as the impact of this worrying development.

  • What makes these cases different?
  • How are various countries handling the outbreak?

The recently published, “The recent outbreak of acute severe hepatitis in children of unknown origin – what is known so far”, will provide you with more information. 

For more information, please visit:

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Moderators

Hermien Hartog is consultant adult and paediatric liver transplant surgeon at the Liver Unit of University Hospitals Birmingham and Birmingham Children’s Hospital, in Birmingham, UK.

Zeuzem Stefan Zeuzem, MD, is a Professor of Medicine and Chief of the Department of Medicine I at the Goethe University Hospital, Frankfurt, Germany. Prof. Zeuzem completed his medical training at the Goethe University Medical School, Frankfurt, Germany; the School of Clinical Medicine, University of Cambridge, UK and the Medical School, University of Newcastle upon Tyne, UK. Prof. Zeuzem subsequently completed postdoctoral fellowships in Endocrinology and Gastroenterology at the University Hospital, Frankfurt, Germany. In addition, he undertook research sabbaticals at the Max Planck Institute for Biophysics, Frankfurt and the Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University Medical School, Connecticut, USA. From 2002 to 2006 he was a full Professor of Medicine and Chairman of the Department of Internal Medicine II at Saarland University Hospital, Homburg/Saar, Germany.
Aleksander Krag Aleksander Krag is EASL Vice-Secretary & Professor and Head of Hepatology at University of Southern Denmark and Odense University Hospital. Main research areas are within complications to cirrhosis, portal hypertension and alcoholic liver disease. He is involved in a number of collaborations, including being Coordinator in the H2020 project GALAXY: Gut and liver axis in alcoholic liver fibrosis.

Faculty

Hermien Hartog is consultant adult and paediatric liver transplant surgeon at the Liver Unit of University Hospitals Birmingham and Birmingham Children’s Hospital, in Birmingham, UK.

Hartorg Hermien Hartog is consultant adult and paediatric liver transplant surgeon at the Liver Unit of University Hospitals Birmingham and Birmingham Children’s Hospital, in Birmingham, UK. She is secretary-elect of the European Liver and Intestine Transplant Association (ELITA), a section of the European Society for Organ Transplantation (ESOT). She completed her surgical training in 2014 and specialized in HPB, liver- and kidney transplant surgery at the Erasmus Medical Centre Rotterdam, the Netherlands, before moving to the UK in 2020. Her current clinical interests and work include adult and paediatric liver transplantation, as well as intestinal transplantation. Her research focusses on perspectives in organ allocation for liver transplant candidates, management of post-transplant complications and patient-reported outcomes.
Philippa Easterbrook

Professor Philippa Easterbrook is Senior Scientist within the Global Hepatitis Programme in the HIV department at the World Health Organisation Headquarters in Geneva. For the last five years she has led the development and implementation of global normative guidance in the use of antiretroviral therapy, and hepatitis B and C management and testing, and support to low and middle-income countries in hepatitis testing and treatment scale-up. She served as Head of Research at the Infectious Diseases Institute, Makerere University, Kampala during a sabbatical. Her research activities have encompassed epidemiology, clinical trials, operational and qualitative research, as well as collaborative pathogenesis studies on the mechanisms of resistance to HIV. She is the technical focal point and health operational pillar lead for the WHO headquarters Incident management team for severe acute hepatitis in children event.

Erika Duffell Dr Erika Duffell is a medically qualified public health professional specialised in the field of communicable disease control. Since 2011, she has worked for the European Centre for Disease Prevention and Control (ECDC) in Stockholm as an epidemiologist working on hepatitis. In this position, she was responsible for the implementation of the hepatitis surveillance, prevention, and control programme across EU/EEA countries. She subsequently led the further development of the regional surveillance programme for hepatitis to include sentinel methods, estimates of prevalence, morbidity and mortality monitoring. Dr Duffell works in close collaboration with partner agencies and related organisations e.g. WHO, EMCDDA, European Commission, etc in order to effectively support EU/EEA countries in their efforts to prevent and control hepatitis.
Log in to post comments

EASL Studio S2 E15: JHEP Live on the best animal model for HCC – Lost in translation?

Description

Mouse models, based on dietary, chemical or genetic interventions, are designed to serve as tools to understand human liver diseases.

With the number of models increasing:

  • What types of models exist for hepatocellular carcinoma?
  • How close do they mirror human liver cancer (subtypes)?
  • Can they be used to predict therapeutic response?
  • What are the best models? For which questions?
  • From idea to conception, are we getting lost in translation?

Read this recent Journal of Hepatology article, on which the discussion was based.

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

 

Moderator

 
Franck Tacke

Frank Tacke is board-certified in Internal Medicine, Gastroenterology, Endocrinology and Diabetology, Critical Care Medicine and Infectious Diseases. He has (co)authored >580 peer-reviewed original and review articles, and he is listed as a “Highly Cited Researcher 2020 and 2021” in the area “cross-field”. He has served on the Governing Board of the EASL (2014-2018) and is currently Co-Editor at the JHEP. Professor Tacke has been appointed in 2019 as the Head of Hepatology and Gastroenterology at the Charité - Universitätsmedizin Berlin, one of Europe’s largest university hospitals and renowned for excellence in medicine.

Faculty

 
Sabine Colnot Sabine Colnot heads a research team entitled “Oncogenic functions of beta-catenin in the liver” of the French National Institute of Health and Medical Research (INSERM), at the Cordeliers Research Center in Paris, France. She specializes in the generation and characterization of mouse genetically-engineered models of liver cancers, with a focus on beta-catenin signaling in Hepatocellular Carcinoma. She discovered the major role of that signaling in patterning the liver metabolic zonation, and in driving a specific hepatocarcinogenesis, requiring targeted therapeutic options.
Tim Greten

Dr Greten is co-chair of the Center of Excellence in Immunology, member of the Center for Advanced Preclinical Research oversight. In 2010 he joined CCR's Medical Oncology Branch as head of the Gastrointestinal Malignancy Section and was promoted as a tenured Senior Investigator in 2015 and Deputy Branch Chief in 2018. Dr Greten has published more than 200 peer-reviewed papers on basic tumor immunology, translational research studies in hepatocellular carcinoma (HCC) as well as on clinical trials in different gastrointestinal malignancies, including HCC.

Mathias Heikenwälder

Prof. Mathias Heikenwaelder is a trained molecular biologist and microbiologist, with expertise in immunology, pathology and a strong link to translational research evoked by 10 years of work and expertise in a Pathology Institution (Clinical Pathology, University Hospital Zurich, Switzerland). Since October 2015 he is heads the Department “Chronic inflammation and Cancer” at the German Cancer Research Center (DKFZ) in Heidelberg focusing on the link between chronic inflammation and cancer, with the main focus on liver cancer. Prof. Heikenwaelder’s laboratory aims at understanding the different immune signatures of chronic inflammatory human diseases driving liver tissue damage and liver cancer using patient material and relevant preclinical mouse models. This is done with the final aim to generate valid pre-clinical models of chronic inflammation induced tissue damage and cancer, used for pre-clinical research. Mathias Heikenwälder has received several awards and prestigious grants (ERC-Starting 2011; ERC-Consolidator 2016; ERC-Proof of concept 2019; Horizon 2020, German Cancer Award 2022) and has become a highly cited researcher in 2019, 2020 and 2021. His credo is to support young researchers to follow their dreams and to support them to become independent.

Jessica Zucman-Rossi

Jessica Zucman-Rossi is Professor of Medicine at University Paris Descartes, within the department of Oncology at the European Hospital Georges Pompidou (AP-HP). She is the director of the Cordeliers Center of Research and of the team “Functional Genomics of Solid Tumors”, with a focus on liver and mesothelial tumors. Her team aims to develop basic genomic approaches based on human tumors analyses to identify new mechanisms of tumorigenesis and to transfer this knowledge into biomarkers that could be introduced in clinical care. In particular, the group was pioneer in the elucidation of the molecular classification of benign and malignant liver tumors. Currently, she is President of the International Liver Cancer Association (ILCA) and she acts as Editor in Chief for the new EASL open access journal “JHEP Reports”.

Log in to post comments

EASL Studio S2 E16: The NAFLD pandemic

Description

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases and a leading cause of hepatocellular carcinoma (HCC) in western countries. NAFLD does not only affect the liver but was shown to be a multisystem disease with increased risk of type 2 diabetes, kidney and cardiovascular diseases.

In honour of the International NASH Day (09 June), EASL Studio will host a special episode on the NAFLD pandemic, the discussions will include:

  • Impact of lifestyles and policies for NAFLD and NASH prevention
  • The complexity of NASH clinical trials
  • Therapeutic approach in patients with HCC and NAFLD/NASH aetiology

This EASL Studio episode is supported by Novo Nordisk A/S and EISAI Europe Ltd.

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

Moderator

 
Philip Newsome Philip Newsome is Professor of Hepatology at the University of Birmingham and Deputy Director at Birmingham NIHR Biomedical Research Centre (BRC). He has a large laboratory group focussing on the role of cell therapy in liver injury and has established three cutting edge clinical trials for which he is the Chief Investigator. He runs the metabolic services at the Liver Unit at the Queen Elizabeth Hospital Birmingham which include a large multi-disciplinary clinic for patients with NAFLD. He is the Co-ordinating Investigator for several global NAFLD studies, he chaired the national guidelines for liver transplantation in NAFLD and sat on the NICE Guideline Development Group for NAFLD. In addition, he led the recent UK multi-stakeholder guideline group on the management of abnormal liver blood tests and led on NAFLD for the recent EASL Lancet Liver Commission.

Faculty

 
Jean-François Dufour

Professor Jean-Francois Dufour studied mathematics at the University of Geneva, Switzerland, and received his medical degree from the Geneva Medical School. After training in internal medicine in Switzerland, he joined the laboratory of Professor I. Arias at Tufts University in Boston, Massachusetts, where he studied the effects of calcium signalling on bile canaliculus. He returned to the clinic to complete a gastroenterology fellowship with Professor M. Kaplan at the New England Medical Center. Then, Professor Dufour established his own laboratory at the University of Bern, Switzerland, where he was clinic director for 10 years. Professor Dufour is a member of the American Association for the Study of Liver Disease (fellow), the American Gastroenterology Association (fellow), the European Association for the Study of the Liver (EASL). He is a founding member of the International Liver Cancer Association. He was twice member of governing board of EASL as scientific committee member and then as educational councillor. He was member of the United European Gastroenterology educational committee. Professor Dufour has a large clinical experience and a broad understanding of basic and translational research, its bottleneck and the challenges in disseminating and exploiting knowledge. Professor Dufour has served as principal investigator on numerous clinical studies, focusing on NASH and hepatocellular carcinoma. He is an associate editor of GUT, and was an associate editor of Hepatology (responsible for the monthly ‘Highlights’ section), Journal of Hepatology and Liver International.

Shira Zelber-Sagi Professor Shira Zelber-Sagi is a full professor and the Head of the School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa. She is a clinical dietitian, Epidemiologist, and researcher with interest in nutritional epidemiology and NAFLD, and other chronic co-morbidities. She is a member of the EASL Policy and Public Health Committee and the United European Gastroenterology (UEG) Policy and Public Health Committee. In addition, she is founder of the Gastroenterology forum of the Israeli dietitians’ association.

Speakers on behalf of industry

 
Daniel Vega Møller

Daniél Vega Møller is Vice President in Clinical Drug Development, Obesity & NASH within Novo Nordisk A/S. He graduated in Medicine at the University of Copenhagen in 2000, where he also obtained his PhD within molecular cardio-genetics and heart failure. He has also been involved in the analysis of different biomarkers and their importance for prediction within the field of hypertension, CVD and obesity. After 10 years in the hospital setting in internal medicine, mainly cardiology, he moved to Novo Nordisk and has been employed for almost 12 years focusing on drug development within the portfolio of insulin, obesity and metabolism leading to approval of new drugs for the benefit of the people with chronic diseases. He is currently overall responsible for the departments driving the clinical development plans within obesity and NASH at the clinical stages of development from phase 1-4, including the exploration of possible diagnostic and prognostic biomarkers.

Andrea Casadei Gardini Professor Andrea Casadei Gardini is a senior researcher and Consultant Medical Oncologist at San Raffaele Hospital (University Vita e Salute), Milan, Italy. Head of liver oncology unit at the same hospital. He leads a translational and clinical research program focusing on hepatocellular carcinoma and cholangiocarcinoma and is a member of the AIOM Guidelines Writing Committee on Hepatocellular Carcinoma. He has been invited to give oral presentations at several international conferences including the Annual conference of the Asian Pacific Association for The Study of the liver 2017; International Liver Cancer Association 2017 (Seoul); International Liver Cancer Association 2018 (London); International Liver Cancer Association 2019 (Chicago) and EASL HCC-summit 2019 (Lisboa).
Log in to post comments

EASL Studio S3 E1: JHEP Live: Covid vaccination and associated autoimmune hepatitis

Description

Several recent reports have postulated a link between autoimmune hepatitis (AIH) following SARS-CoV-2 infection or vaccination. This EASL Studio JHEP Live discuss the potential links between COVID-19 and AIH.

Faculty

  • Prof. Vlad Ratziu (Moderator)
  • Prof. Naga Chalasani (Moderator)
  • Prof. Fernando Bril (Faculty)
  • Prof. Robert Fontana (Faculty)
  • Dr Johannes Hartl (Faculty)

ℹ️ More information on the topic can be found in these articles:

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Log in to post comments

EASL Studio S3 E2: Liver transplantation for ACLF: Opportunities, challenges and pitfalls

Description

This EASL Studio discusses important issues related to the opportunities and challenges of liver transplantation in acute-on-chronic liver failure (ACLF).

  • Does urgent liver transplantation improve the survival of patients with ACLF-3 and where are the limits?
  • Are the current allocation systems adequate and how to implement ACLF criteria for prioritisation?
  • The distinct lack of equity of access of ACLF-3 patients to liver transplantation: Where are the barriers?
  • What data will the CHANCE study deliver to address some of the unanswered questions?

Faculty

  • Prof. Rajiv Jalan (Moderator)
  • Dr Thierry Artzner (Faculty)
  • Prof. Luca Belli (Faculty)
  • Prof. Marina Berenguer (Faculty)

Patient perspective

  • Dr Amit Verma (United Kingdom)
  • Dr Devangi Verma (United Kingdom)

ℹ️ Please click here to access the podcast version of this EASL Studio episode.

 

Log in to post comments