Decompensated cirrhosis

Course details

Modules (2)

Course Duration:

2 hours

You can start, leave and pick up where you left off at your own pace!

Course Credits:

Up to 2 CME credits

Assessment & Awards:

award CC

About this course

Decompensated cirrhosis affects over 10 million people worldwide and is the cause of mortality of about 2 million people yearly. Death rates remain largely unchanged, despite escalating healthcare costs. The clinical and prognostic models of decompensated cirrhosis have been studied extensively in the past 20 years, leading up to the identification of a newly defined clinical entity: acute-on chronic liver failure.

Emerging data from studies on the pathophysiological basis of decompensated cirrhosis has identified systemic inflammation as being central to the progression of liver disease and mortality. This new understanding is leading to rapid changes in the approaches to the management of cirrhotic patients, design of clinical trials, and selection of patients for early liver transplantation.

In recognition of the exciting new developments in the field, EASL and the Journal of Hepatology are planning to publish a special Supplement summarising the current literature authored by leaders in the field. These two EASL webinars have been designed to allow the authors to critically discuss recent advances in decompensated cirrhosis with the audience.

Benefits for learners

  • Latest evidence-based clinical recommendations
  • Critical topical discussions
  • CME from the European Union of Medical Specialists (UEMS)


  • Understand the changing epidemiology of cirrhosis
  • Learn about new perspectives in the trajectory of cirrhosis and why acute on chronic liver failure should be considered a distinct clinical entity
  • Understand the role of systemic inflammation and how this fits into the established pathophysiological mechanisms of decompensated cirrhosis
  • Understand how the management of decompensated cirrhosis is changing, the concept of disease modifying agents and issue of working beyond guidelines
  • How sarcopenia and frailty impact on outcomes, their assessment and therapeutic approaches
  • Exploring nuances in the intensive care management of patients with ACLF and the role of liver transplantation
  • Hepatologists, gastroenterologists
  • Transplant surgeons
  • General practitioners
  • Health care professionals

1. Disease Trajectory and Pathophysiology (1 hour, 1 CME credit, release date: June 2021)

with Prof. Rajiv Jalan, Prof. Gyongyi Szabo, Prof. Peter Jepsen, Prof. Thierry Gustot, Prof. Jonel Trebicka & Dr Shilpa Chokshi

2. Management and Liver Transplantation (1 hour, 1 CME credit, release date: June 2021)

with Prof. Paolo Angeli, Prof. Marina Berenguer, Prof. Patrizia Burra, Prof. Puneeta Tandon, Prof. Raj Mookerjee & Prof. William Bernal

  1. In each module, complete the Pre Knowledge Check to determine your current level of understanding. This is not counted as part of your grade for this course.
  2. After completing the Pre Knowledge Check you can watch the lecture.
  3. After watching the lecture you will unlock the Post Knowledge Check.
  4. Once you pass the Post Knowledge Check you will need to provide some module feedback on the module in order to unlock your Module Certificate and your CME Credits Certificate.
  5. Continue with the next module.

The course is available through desktop and mobile devices on all internet browsers (e.g. Safari, Microsoft Edge, Chrome and Firefox). ou can also take this course using the Moodle app, please follow the below instructions if you are running the app for the first time. If you have already access the EASL Campus via the Moodle app, just go to step 5:

  1. Download the free Moodle app from your favourite application store
  2. Launch the app and under "Your site" enter:
  3. Choose "Log in using your account on: EASL"
  4. Enter the credentials of your MyEASL account. If you do not have an account yet, please create one for free here
  5. Click on the three dots icon at the bottom right corner of your screen and select "Scan QR Code" 
  6. Scan the below QR code to access this course: 
  7. Start the course

Completing this course will grant you with an EASL "Certificate of Completion" and up to two European CME credits as well as experience points to collect the topic-related and bookworm badges.