CT scan reveals multiple lesions in the spleen, lung, adrenal gland and soft tissue (muscle), suspicious of metastasis. A biopsy from the subcutaneous lesion confirms metastatic recurrence of HCC. AFP and liver function tests are within the normal range, and kidney function is only slightly impaired (eGFR 70 ml/min/ 1.73 m3).
Which of the following systemic treatment options should be considered?
