For the first EASL Journal Club we took a closer look at a study that investigated the metabolic effects of daily sugar sweetened beverage consumption in healthy lean men. It revealed that beverages sweetened with the sugars fructose and sucrose (glucose and fructose combined), but not glucose, increase the ability of the liver to produce lipids.

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  • Elinam Gayi

    The Live Journal Club is over, but you can continue the discussion here.

  • Bettina Geidl

    It was relatively easy to obtain the approvement. All expected metabolic alterations were expected to be reversible. The infusion protocols were all established and the risk for participant considered to be low

  • Marta Afonso

    How easy is to get a clinical trial like this approved? and What were the main Ethical considerations and concerns? Because this clinical trial instead of testing a therapeutic strategy, tested the impact of drinking sweetened beverages, which is already known to be harmful to those involved.

  • Laurent Perrin

    Since liver lipid metabolism is controlled by the circadian clock and feeding, and that glucose is a potent clock synchronizer, did you control the time window of meal by the participants?

  • Bettina Geidl

    The participants were asked to go on with their eating habbits. We did not control for the time..

  • Marta Afonso

    If you're having trouble posting comments, don't forget to log in
    Let's contribute for a lively and fruitful discussion.

  • Rui Castro

    Recent dietary animal models of NAFLD/NASH are based on high-fat diets in combination with different sugars in drinking water (to mimic a "fast food" diet). Do you think the effects of each sugar would be different if participants were on a high fat diet? Would the effect be additive or higher? Would glucose still remain the "better" sugar?

  • Bettina Geidl

    I doubt that high-fat in addition to SSB would have changed our findings regarding lipogenic acitivity of the liver (primary outcome of the study). It would be interesting to know how a high-fat/high fructose intervention impacts liver fat...I suppose that the problem with a high-fat/fructose intervention would be that it leads to excessive caloric intake which confounds results...

  • Mounia Heddad Masson

    Are all the sugars equal??

  • Mounia Heddad Masson

    Why is there so much succrose/fructose in drinks?

  • Bettina Geidl

    It must be due to palatability provided by the drinks. The commercially available drinks contain sugar, but also acid. Without acid, drinks are not palatable (our study drinks tasted very sweet)

  • Marta Afonso

    The adictive power of sugar

  • Mounia Heddad Masson

    You can address your questions to the faculty through the chat and/or twitter using #EASLJC!

  • Marta Afonso

    Welcome to the first Journal club. I would encourage you to post your questions here and I will take them to the moderators and the authors.

  • Marta Afonso

    Ready for the first EASL Journal Club?

  • Mounia Heddad Masson

    Yes! We are looking forward to the discussions!

  • Elinam Gayi

    The EASL Journal Club will start in less than an hour!
    Use this space to discuss the article or comment on the faculty's conversation.
    If you have any questions post them here, Marta Afonso will make sure the faculty answers them.

Prof. Verena Keitel
Verena Keitel
Educational Committee Member and Moderator
Portrait of Dr. Elsharkawy
Ahmed Elsharkawy
Chair & Internal Affairs Councillor
Portrait of Prof. Tacke
Frank Tacke
JHEP Co-Editor
Portait of Dr. Geidl
Bettina Geidl
Author and Presenter
Portrait of Dr. Gerber
Philipp Gerber
Senior Author
Amalia Gastaldelli
Amalia Gastaldelli
The Challenger
Portrait of Dr. Afonso
Marta Afonso
Chair and YI Task Force Member
Portrait of Dr. Banales
Jesús Bañales
JHEP Web/Social Media Editor
Elliot Tapper
Elliot Tapper
JHEP Web/Social Media Editor

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Terry Fannon
Laurent Perrin
Robert Kilpatrick
Robert Kilpatrick
Hanns-Ulrich Marschall
Hanns-Ulrich Marschall
Mounia Heddad Masson
Anjan Banerjee
Anjan Banerjee
Philipp Schwabl
VASILIKI LYGOURA
VASILIKI LYGOURA
Maurizio Bonacini
Maurizio Bonacini
george markakis
george markakis
Boby Pratama Putra
Boby Pratama Putra
Jang Han Jung
Jang Han Jung
Thanh Kim
sachin sharma
sachin sharma
Brian K Chung
Brian K Chung
Laura Daguerre
Giordano Sigon
Giordano Sigon
Helena Greenfield
Helena Greenfield
Eric Kauffman-Ortega
Eric Kauffman-Ortega
Rana Maher
Rana Maher
simona  sehrish
simona sehrish
Camilla Ritieni
Camilla Ritieni
Saeed hoorang
Saeed hoorang
Henry Liu
Henry Liu
Tareg abuzaid
Tareg abuzaid
Rajesh  Dey
Rajesh Dey
Kayalvizhi Jayaraman
Kayalvizhi Jayaraman
David Samuel
David Samuel
Hatice Gulgun FIRAT
Ana Craciun
Ana Craciun
Rui Castro
Rui Castro
Sara Guerra
Sara Guerra
Mashita Nurrabbani
Mashita Nurrabbani
Juan TURNES VAZQUEZ
Juan TURNES VAZQUEZ
Maria Reich
Maria Reich
Maria Antonella Burza
Maria Antonella Burza
Marta Afonso
Marta Afonso
Elinam Gayi
OLGA R. METİN
OLGA R. METİN
André Cardador
André Cardador
Gocha G. Barbakadze
Gocha G. Barbakadze
Iva Košuta
Iva Košuta
David Marti Aguado
David Marti Aguado
Antonio GALANTE
Antonio GALANTE