Description

Decompensated cirrhosis affects over 10 million people worldwide and is the cause of mortality of about 2 million people yearly. Death rates remain largely unchanged, despite escalating healthcare costs. The clinical and prognostic models of decompensated cirrhosis have been studied extensively in the past 20 years, leading up to the identification of a newly defined clinical entity: acute-on chronic liver failure. Emerging data from studies on the pathophysiological basis of decompensated cirrhosis has identified systemic inflammation as being central to the progression of liver disease and mortality. This new understanding is leading to rapid changes in the approaches to the management of cirrhotic patients, design of clinical trials, and selection of patients for early liver transplantation. In recognition of the exciting new developments in the field, EASL and the Journal of Hepatology are planning to publish a special supplement summarising the current literature authored by leaders in the field. These two EASL webinars have been designed to allow the authors to critically discuss recent advances in decompensated cirrhosis with the audience.

 

Targeted Audience

  • Hepatologists, gastroenterologists
  • Transplant surgeons
  • General practitioners
  • Health care professionals

 

Learning Objectives

  • Understand the changing epidemiology of cirrhosis
  • Learn about new perspectives in the trajectory of cirrhosis and why acute on chronic liver failure should be considered a distinct clinical entity
  • Understand the role of systemic inflammation and how this fits into the established pathophysiological mechanisms of decompensated cirrhosis
  • Understand how the management of decompensated cirrhosis is changing, the concept of disease modifying agents and issue of working beyond guidelines
  • How sarcopenia and frailty impact on outcomes, their assessment and therapeutic approaches
  • Exploring nuances in the intensive care management of patients with ACLF and the role of liver transplantation

 

Webinar 1: Disease Trajectory and Pathophysiology

This first webinar took place on 25.05.2021. Access the on-demand webinar here.

Time Title
18:00-18:05

Welcome and Introduction

Rajiv Jalan, University College London Medical School, United Kingdom

Gyongyi Szabo, Beth Israel Deaconess Medical Center, United States of America

18:05-18:20

Changing Epidemiology and Healthcare burden

Peter Jepsen, University of Aarhus, Denmark

18:20-18:35

Disease Trajectory and New tools for stratification 

Thierry Gustot, Université Libre de Bruxelles, Belgium

18:35-18:50

Pathophysiological basis of Decompensated Cirrhosis

Jonel Trebicka, University Goethe Frankfurt am Main, Germany

18:50-19:05

Immune dysfunction in cirrhosis

Shilpa Chokshi, Institute of Hepatology and Foundation for Liver Research, United Kingdom

19:05-19:30

Discussion and Q&A

All

 

Webinar 2: Management and Liver Transplantation

This second webinar took place on 01.06.2021.Access the on-demand webinar here.

Time Title
18:00-18:05

Welcome and Introduction

Paolo Angeli, University of Padova, Italy

Marina Berenguer, University of Valencia, Spain

18:05-18:20

Intensive Care Management

William Bernal, Kings College London, United Kingdom

18:20-18:35

Established and Novel therapies for decompensated cirrhosis 

Raj Mookerjee, University College London, United Kingdom

18:35-18:50

Assessment and management of  Sarcopenia and Frailty

Puneeta Tandon, University of Alberta, Canada

18:50-19:05

Changing rules for transplanting patients with decompensated cirrhosis

Patrizia Burra, University of Padova, Italy

19:05-19:30

Discussion and Q&A

All